2431 Transscleral contact-cyclophotocoagulation: Is there a dose-effect correlation?

Purpose: Transscleral contect-cyclophotocoagulation has been used more end more in the treatment of therapy-refractive glaucomas, in recent years. A less pain sensation, reported by the patients, during b-eatment in comparison with cycle-cryocoagulatio was one important reason for increased usuage. The dose-effect correlation for exposure time, energy used and number of the laser impacts various according to different authors. This retrospective study (tied to d&tine if there is a dw-effect correlation of the tmnssclerai contaet-cyclophotoccegulation. Methods: 124 eyes of I13 patients (62 female, 62 male, range of age 49.9 f 26,5 years) were included in this study according to their diagnosis (congerdbd ghwwma. secundary glaucoma, primary opm glaucoma, small angle glaucoma). The used energy, number of laser impacts, exposure time and laserpower were reviewed along with the intm-wular pressurn (IOP) before treatment, after treatment and during the follow-up (mean 6 months). A medication-score was used to register the antiglaucomatous drugs. Results: 45.2 % (56) of 124 eyes had an IOP of < 22 mm Hg. 25.8 96 (32) were treated up to live times. A clinical correlation between energy and decrease of IOP was not found (p, = 0,0815 non significant, speermann rank-correlation). The IOP was reduced sigoificantly from 35.8 f 10.5 mm Hg pre-op lo 263 f 10.5 mm Hg at the end of follow-up (p = 0, WilcoxanTest). Up to 3 antiglaucomatous drugs could be saved in therapy-refractive eyes to reach an IOP of 21 mm Hg or less. Conclusions: This data shows that a decrease about 10 mm Hg of the IOP is possible using Ihe transsclwal fontact-cyclophotocO~oa. In therapyrefractive eyes. less drugs were needed to reach so IOP < 22 mm Hg. Regardless the diagnosis, a dose-effect correlation between the decrease of IOP aad laser energy was not found.